PELI1
PELI1，全稱為Pellino E3泛素蛋白連接酶1，常用別名包括PELI和PELI-1。它在人體免疫過程中扮演關(guān)鍵角色，通過對特定蛋白質(zhì)進(jìn)行修飾，調(diào)控免疫細(xì)胞的激活狀態(tài)與炎癥反應(yīng)的程度。比如當(dāng)身體遭遇病原體入侵時(shí)，它會(huì)參與調(diào)節(jié)免疫相關(guān)的反應(yīng)過程，幫助維持免疫應(yīng)答的平衡，避免反應(yīng)過強(qiáng)引發(fā)組織損傷或過弱導(dǎo)致感染擴(kuò)散。
PELI1功能異常可能與多種疾病相關(guān)。在類風(fēng)濕關(guān)節(jié)炎等自身免疫病中，PELI1的表達(dá)或活性變化可能導(dǎo)致炎癥失控；部分腫瘤里也發(fā)現(xiàn)它參與細(xì)胞增殖和轉(zhuǎn)移的過程。目前針對PELI1的藥物研發(fā)仍處于早期探索階段，研究人員正嘗試開發(fā)能調(diào)節(jié)其活性的化合物，希望為相關(guān)免疫疾病和腫瘤的治療提供新的靶點(diǎn)與方案。
熱銷產(chǎn)品
Recombinant Human E3 ubiquitin-protein ligase pellino homolog 1 (PELI1) (CSB-BP856932HUb0)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PELI1 Antibody (CSB-PA856932ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: PELI1 antibody at 7µg/ml
Lane 1: HL60 whole cell lysate
Lane 2: Mouse liver tissue
Lane 3: THP-1 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 46 kDa
Observed band size: 46 kDa
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA856932ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA856932ESR1HU at dilution of 1:100
PELI1 Antibodies
PELI1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA017775GA01HU | PELI1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA856932ESR1HU | PELI1 Antibody | Human, Mouse | ELISA, WB, IHC |
PELI1 Proteins
PELI1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP856932HU CSB-EP856932HU CSB-BP856932HU CSB-MP856932HU CSB-EP856932HU-B |
Recombinant Human E3 ubiquitin-protein ligase pellino homolog 1 (PELI1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP856932HUe0 | Recombinant Human E3 ubiquitin-protein ligase pellino homolog 1 (PELI1) | E.coli |
| CSB-BP856932HUb0 | Recombinant Human E3 ubiquitin-protein ligase pellino homolog 1 (PELI1) | Baculovirus |
| CSB-EP856932HUa0 | Recombinant Human E3 ubiquitin-protein ligase pellino homolog 1 (PELI1) | E.coli |
