PGAM5
PGAM5全稱為磷酸甘油酸變位酶5，是一種錨定在線粒體膜上的蛋白，常參與細胞內的應激響應與功能平衡調節。它就像細胞內的“微調器”，能根據細胞的能量狀態和損傷程度調整線粒體的運作模式——當細胞面臨氧化壓力或代謝紊亂時，它可能改變線粒體膜的通透性，影響細胞的生存走向：既可以幫助細胞適應短暫應激，也可能在損傷過重時推動細胞凋亡或壞死。
PGAM5異常與多種疾病關聯緊密。比如在帕金森病等神經退行性疾病中，它的活性失衡可能加劇神經元的線粒體損傷，加速疾病進展；在某些炎癥性疾病或腫瘤里，它也可能通過調控細胞的應激耐受，成為疾病發展的潛在推手。目前針對PGAM5的藥物研發仍處于基礎研究階段，研究者們在探索能精準調節其功能的化合物，希望為線粒體相關疾病提供新的治療方向，但尚未有成熟藥物進入臨床。
熱銷產品
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PGAM5 Antibody (CSB-PA839338LA01HU)
驗證數據
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA839338LA01HU at dilution of 1: 100
Immunofluorescent analysis of Hela cells using CSB-PA839338LA01HU at dilution of 1: 100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
PGAM5 Antibodies
PGAM5 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA839338LA01HU | PGAM5 Antibody | Human | ELISA, IHC, IF |
| CSB-PA839338LB01HU | PGAM5 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA839338LC01HU | PGAM5 Antibody, FITC conjugated | Human | |
| CSB-PA839338LD01HU | PGAM5 Antibody, Biotin conjugated | Human | ELISA |
PGAM5 Proteins
PGAM5 Proteins for Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP451856DLL CSB-EP451856DLL CSB-BP451856DLL CSB-MP451856DLL CSB-EP451856DLL-B |
Recombinant Drosophila grimshawi Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PGAM5 Proteins for Drosophila mojavensis (Fruit fly)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP453812DLY CSB-EP453812DLY CSB-BP453812DLY CSB-MP453812DLY CSB-EP453812DLY-B |
Recombinant Drosophila mojavensis Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PGAM5 Proteins for Drosophila erecta (Fruit fly)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP455403DLK CSB-EP455403DLK CSB-BP455403DLK CSB-MP455403DLK CSB-EP455403DLK-B |
Recombinant Drosophila erecta Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PGAM5 Proteins for Drosophila ananassae (Fruit fly)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP457291DKY CSB-EP457291DKY CSB-BP457291DKY CSB-MP457291DKY CSB-EP457291DKY-B |
Recombinant Drosophila ananassae Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PGAM5 Proteins for Drosophila virilis (Fruit fly)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP457693DMP CSB-EP457693DMP CSB-BP457693DMP CSB-MP457693DMP CSB-EP457693DMP-B |
Recombinant Drosophila virilis Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PGAM5 Proteins for Drosophila yakuba (Fruit fly)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP457718DMR CSB-EP457718DMR CSB-BP457718DMR CSB-MP457718DMR CSB-EP457718DMR-B |
Recombinant Drosophila yakuba Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PGAM5 Proteins for Drosophila simulans (Fruit fly)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP457728DMJ CSB-EP457728DMJ CSB-BP457728DMJ CSB-MP457728DMJ CSB-EP457728DMJ-B |
Recombinant Drosophila simulans Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PGAM5 Proteins for Drosophila persimilis (Fruit fly)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP463491DMB CSB-EP463491DMB CSB-BP463491DMB CSB-MP463491DMB CSB-EP463491DMB-B |
Recombinant Drosophila persimilis Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PGAM5 Proteins for Drosophila sechellia (Fruit fly)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP463506DMG CSB-EP463506DMG CSB-BP463506DMG CSB-MP463506DMG CSB-EP463506DMG-B |
Recombinant Drosophila sechellia Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PGAM5 Proteins for Drosophila willistoni (Fruit fly)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP465488DMQ CSB-EP465488DMQ CSB-BP465488DMQ CSB-MP465488DMQ CSB-EP465488DMQ-B |
Recombinant Drosophila willistoni Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PGAM5 Proteins for Drosophila melanogaster (Fruit fly)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP524299DLU CSB-EP524299DLU CSB-BP524299DLU CSB-MP524299DLU CSB-EP524299DLU-B |
Recombinant Drosophila melanogaster Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PGAM5 Proteins for Drosophila pseudoobscura pseudoobscura (Fruit fly)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP645873DME CSB-EP645873DME CSB-BP645873DME CSB-MP645873DME CSB-EP645873DME-B |
Recombinant Drosophila pseudoobscura pseudoobscura Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PGAM5 Proteins for Xenopus laevis (African clawed frog)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP685921XBE CSB-EP685921XBE CSB-BP685921XBE CSB-MP685921XBE CSB-EP685921XBE-B |
Recombinant Xenopus laevis Serine/threonine-protein phosphatase PGAM5, mitochondrial (pgam5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PGAM5 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP687927RA CSB-EP687927RA CSB-BP687927RA CSB-MP687927RA CSB-EP687927RA-B |
Recombinant Rat Serine/threonine-protein phosphatase PGAM5, mitochondrial (Pgam5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PGAM5 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP709473DIL CSB-EP709473DIL CSB-BP709473DIL CSB-MP709473DIL CSB-EP709473DIL-B |
Recombinant Danio rerio Serine/threonine-protein phosphatase PGAM5, mitochondrial (pgam5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PGAM5 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP750175XBF CSB-EP750175XBF CSB-BP750175XBF CSB-MP750175XBF CSB-EP750175XBF-B |
Recombinant Xenopus tropicalis Serine/threonine-protein phosphatase PGAM5, mitochondrial (pgam5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PGAM5 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP805980MO CSB-EP805980MO CSB-BP805980MO CSB-MP805980MO CSB-EP805980MO-B |
Recombinant Mouse Serine/threonine-protein phosphatase PGAM5, mitochondrial (Pgam5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PGAM5 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-MP839338HU CSB-EP839338HU-B |
Recombinant Human Serine/threonine-protein phosphatase PGAM5, mitochondrial (PGAM5), partial | Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP839338HU | Recombinant Human Serine/threonine-protein phosphatase PGAM5,mitochondrial (PGAM5), partial | E.coli |
| CSB-EP839338HUc7 | Recombinant Human Serine/threonine-protein?phosphatase PGAM5,mitochondrial (PGAM5), partial | E.coli |
| CSB-YP839338HU | Recombinant Human Serine/threonine-protein phosphatase PGAM5, mitochondrial (PGAM5), partial | Yeast |
| CSB-BP839338HU | Recombinant Human Serine/threonine-protein phosphatase PGAM5, mitochondrial (PGAM5), partial | Baculovirus |
| CSB-CF839338HU(A4)(M) | Recombinant Human Serine/threonine-protein phosphatase PGAM5,mitochondrial (PGAM5) (G166A,V167A,K169A) | in vitro E.coli expression system |
