PIAS3
PIAS3，全稱為蛋白抑制劑活化STAT3，常用別名STAT3抑制劑。它是細胞內信號調控蛋白，廣泛表達于人體各類組織，參與信號傳導、基因轉錄調控，主要通過抑制STAT3信號通路，調控細胞增殖、分化、凋亡及免疫平衡，維持機體正常生理穩態。 PIAS3表達異常與多種疾病密切相關，表達不足會導致STAT3信號過度激活，促進腫瘤細胞增殖、侵襲及免疫抑制，與肺癌、乳腺癌、白血病等腫瘤相關；異常表達則會影響免疫信號傳導，誘發自身免疫病。目前PIAS3激活劑處于臨床前研究階段，通過抑制STAT3信號，為腫瘤及自身免疫病提供治療思路。
熱銷產品
Recombinant Human E3 SUMO-protein ligase PIAS3 (PIAS3), partial (CSB-EP896765HU1)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PIAS3 Antibody (CSB-PA896765DSR1HU)
驗證數據
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA896765DSR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA896765DSR1HU at dilution of 1:100
PIAS3 Antibodies
PIAS3 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA017959GA01HU | PIAS3 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA896765DSR1HU | PIAS3 Antibody | Human | ELISA, IHC |
| CSB-PA283252 | PIAS3 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA003780 | PIAS3 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
PIAS3 Proteins
PIAS3 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017959MO CSB-EP017959MO CSB-BP017959MO CSB-MP017959MO CSB-EP017959MO-B |
Recombinant Mouse E3 SUMO-protein ligase PIAS3 (Pias3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PIAS3 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017959RA CSB-EP017959RA CSB-BP017959RA CSB-MP017959RA CSB-EP017959RA-B |
Recombinant Rat E3 SUMO-protein ligase PIAS3 (Pias3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PIAS3 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP896765HU CSB-EP896765HU CSB-BP896765HU CSB-MP896765HU CSB-EP896765HU-B |
Recombinant Human E3 SUMO-protein ligase PIAS3 (PIAS3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP896765HU1 | Recombinant Human E3 SUMO-protein ligase PIAS3 (PIAS3), partial | E.coli |
