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PIK3R1

PIK3R1,全稱為磷脂酰肌醇3-激酶調節亞基1,常用別名是p85α。它是PI3K蛋白復合物的關鍵組成部分,與催化亞基協同工作,幫助細胞接收外界信號并傳遞到內部,從而調控細胞的生長、分裂和存活狀態。
當PIK3R1出現異常時,可能導致細胞信號傳遞紊亂,進而引發多種疾病:比如在乳腺癌、肺癌等惡性腫瘤中,它的突變或表達變化常與細胞不受控增殖相關;此外,它也參與代謝和免疫相關的生理過程,功能異常還可能和糖尿病、某些遺傳性免疫疾病存在關聯。目前,針對該蛋白相關的細胞信號調節,已有一些藥物處于研發或臨床試驗階段,試圖通過靶向調節其功能來治療相關疾病,但具體療效仍需進一步臨床驗證。

熱銷產品

PIK3R1 Recombinant Monoclonal Antibody (CSB-RA596783A0HU)

驗證數據

CSB-RA596783A0HU

Flow cytometric analysis of PI3 Kinase p85 alpha expression in C2C12 cells using PI3 Kinase p85 alpha antibody. Green, isotype control; red, PI3 Kinase p85 alpha.

CSB-RA596783A0HU

Immunocytochemical staining of C2C12 cells with PI3 Kinase p85 alpha antibody. Nuclei were stained blue with DAPI; PI3 Kinase p85 alpha was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.

CSB-RA596783A0HU

Western blotting analysis using PI3 Kinase p85 alpha antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with PI3 Kinase p85 alpha antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.

PIK3R1 Antibody (CSB-PA018003LA01HU)

驗證數據

CSB-PA018003LA01HU

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA018003LA01HU at dilution of 1:100

CSB-PA018003LA01HU

Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA018003LA01HU at dilution of 1:100

PIK3R1 Antibodies

PIK3R1 for Homo sapiens (Human)

PIK3R1 Proteins

PIK3R1 Proteins for Homo sapiens (Human)

PIK3R1 Proteins for Mus musculus (Mouse)

PIK3R1 Proteins for Bos taurus (Bovine)

PIK3R1 Proteins for Pongo abelii (Sumatran orangutan)

PIK3R1 Proteins for Rattus norvegicus (Rat)



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