PLP1
PLP1，全稱為髓鞘蛋白脂蛋白1，常見別名包括PLP和DM20（后者是其剪接異構(gòu)體）。這種蛋白是中樞神經(jīng)系統(tǒng)內(nèi)少突膠質(zhì)細(xì)胞合成的髓鞘核心成分，對(duì)維持髓鞘的結(jié)構(gòu)完整與功能穩(wěn)定至關(guān)重要，能幫助神經(jīng)信號(hào)在神經(jīng)元間快速傳遞。當(dāng)PLP1出現(xiàn)異常時(shí)，易引發(fā)Pelizaeus-Merzbacher病（PMD）——一種X連鎖遺傳的白質(zhì)腦病，患者常表現(xiàn)出運(yùn)動(dòng)發(fā)育遲緩、肢體僵硬、眼球震顫等癥狀，嚴(yán)重影響生活質(zhì)量。目前針對(duì)PMD尚無根治手段，臨床多采用康復(fù)訓(xùn)練等支持療法；不過科研領(lǐng)域已有進(jìn)展，例如反義寡核苷酸藥物正嘗試糾正PLP1的異常剪接，基因治療也在探索通過載體遞送正?；蚋纳瓢Y狀，這些療法仍處于臨床試驗(yàn)階段，為患者帶來了潛在希望。
熱銷產(chǎn)品
Recombinant Human Myelin proteolipid protein (PLP1) (CSB-CF018202HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PLP1 Antibody (CSB-PA018202LA01HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: PLP1 antibody at 4µg/ml
Lane 1: Hela whole cell lysate
Lane 2: HL60 whole cell lysate
Lane 3: K562 whole cell lysate
Lane 4: THP-1 whole cell lysate
Lane 5: U937 whole cell lysate
Lane 6: A549 whole cell lysate
Lane 7: Caco-2 whole cell lysate
Lane 8: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 31, 27 kDa
Observed band size: 31 kDa
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA018202LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA018202LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
PLP1 Antibodies
PLP1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA018202LA01HU | PLP1 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA018202LB01HU | PLP1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA018202LC01HU | PLP1 Antibody, FITC conjugated | Human | |
| CSB-PA018202LD01HU | PLP1 Antibody, Biotin conjugated | Human | ELISA |
PLP1 Proteins
PLP1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018202HU1 CSB-EP018202HU1 CSB-BP018202HU1 CSB-MP018202HU1 CSB-EP018202HU1-B |
Recombinant Human Myelin proteolipid protein (PLP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF018202HU | Recombinant Human Myelin proteolipid protein (PLP1) | in vitro E.coli expression system |
| CSB-MP018202HU | Recombinant Human Myelin proteolipid protein (PLP1)-VLPs | Mammalian cell |
