PPP1R15A
PPP1R15A，全稱為蛋白磷酸酶1調(diào)節(jié)亞基15A，常用別名GADD34。它是細(xì)胞內(nèi)蛋白磷酸酶1的調(diào)節(jié)亞基，廣泛表達(dá)于人體各類組織，參與細(xì)胞應(yīng)激應(yīng)答、蛋白磷酸化調(diào)控及細(xì)胞凋亡調(diào)控，對(duì)細(xì)胞穩(wěn)態(tài)、DNA損傷修復(fù)及炎癥反應(yīng)具有重要作用，在細(xì)胞受到應(yīng)激時(shí)顯著表達(dá)。 PPP1R15A異常表達(dá)與多種疾病密切相關(guān)，異常高表達(dá)會(huì)導(dǎo)致細(xì)胞應(yīng)激應(yīng)答紊亂，與神經(jīng)退行性疾病、腫瘤相關(guān)，在肺癌、乳腺癌等腫瘤中高表達(dá)，促進(jìn)腫瘤細(xì)胞耐藥及凋亡抵抗；表達(dá)不足則會(huì)加劇細(xì)胞損傷。目前PPP1R15A抑制劑處于臨床前研究階段，通過調(diào)控其應(yīng)激應(yīng)答功能，為腫瘤及神經(jīng)疾病提供治療思路。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PPP1R15A Antibody (CSB-PA787946)
驗(yàn)證數(shù)據(jù)
Western blot analysis of MOUSE-BRAIN lysate, antibody was diluted at 1000. Secondary antibody was diluted at 1:20000
PPP1R15A Antibodies
PPP1R15A for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA018528GA01HU | PPP1R15A Antibody | Human | ELISA,WB |
| CSB-PA787946 | PPP1R15A Antibody | Human | WB,ELISA |
PPP1R15A Proteins
PPP1R15A Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018528MO CSB-EP018528MO CSB-BP018528MO CSB-MP018528MO CSB-EP018528MO-B |
Recombinant Mouse Protein phosphatase 1 regulatory subunit 15A (Ppp1r15a), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPP1R15A Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018528HU | Recombinant Human Protein phosphatase 1 regulatory subunit 15A (PPP1R15A), partial | Yeast |
| CSB-EP018528HU CSB-BP018528HU CSB-MP018528HU CSB-EP018528HU-B |
Recombinant Human Protein phosphatase 1 regulatory subunit 15A (PPP1R15A), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP018528HUa0 | Recombinant Human Protein phosphatase 1 regulatory subunit 15A (PPP1R15A), partial | E.coli |
PPP1R15A Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP642521BO CSB-EP642521BO CSB-BP642521BO CSB-MP642521BO CSB-EP642521BO-B |
Recombinant Bovine Protein phosphatase 1 regulatory subunit 15A (PPP1R15A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPP1R15A Proteins for Cricetulus longicaudatus (Long-tailed dwarf hamster) (Chinese hamster)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP723309DXV CSB-EP723309DXV CSB-BP723309DXV CSB-MP723309DXV CSB-EP723309DXV-B |
Recombinant Cricetulus longicaudatus Protein phosphatase 1 regulatory subunit 15A (Ppp1r15a), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPP1R15A Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP746925RA CSB-EP746925RA CSB-BP746925RA CSB-MP746925RA CSB-EP746925RA-B |
Recombinant Rat Protein phosphatase 1 regulatory subunit 15A (Ppp1r15a) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
