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PRICKLE1

Prickle-like protein 1 is a protein in humans that is encoded by PRICKLE1 gene. Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor.

PRICKLE1 Proteins

PRICKLE1 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

PRICKLE1 Proteins for Mus musculus (Mouse)

PRICKLE1 Proteins for Rattus norvegicus (Rat)

PRICKLE1 Proteins for Homo sapiens (Human)



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