PTGDR2
PTGDR2，全稱為前列腺素D2受體2，常用別名是CRTH2。它能與前列腺素D2結(jié)合，這種結(jié)合會(huì)影響嗜酸性粒細(xì)胞、Th2細(xì)胞等免疫細(xì)胞的活動(dòng)——比如促使這些細(xì)胞向炎癥部位遷移、增強(qiáng)它們的活性，進(jìn)而參與身體的過敏和炎癥反應(yīng)。哮喘患者體內(nèi)這個(gè)蛋白質(zhì)的活性常異常升高，會(huì)加重氣道炎癥與收縮，導(dǎo)致呼吸不暢；過敏性鼻炎、特應(yīng)性皮炎等過敏性疾病的發(fā)生發(fā)展，也和它的功能失調(diào)密切相關(guān)。目前，針對(duì)CRTH2的藥物研發(fā)正在推進(jìn)，一些能阻斷它與前列腺素D2結(jié)合的藥物已進(jìn)入臨床試驗(yàn)階段，這些藥物有望通過抑制免疫細(xì)胞過度活化，緩解過敏性疾病癥狀，為患者提供新的治療選擇。
熱銷產(chǎn)品
Recombinant Human Prostaglandin D2 receptor 2 (PTGDR2) (CSB-CF896745HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PTGDR2 Antibody (CSB-PA005651)
驗(yàn)證數(shù)據(jù)
Western Blot analysis of 293 cells using CD294 Polyclonal Antibody.
PTGDR2 Antibodies
PTGDR2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA005651 | PTGDR2 Antibody | Human,Mouse | WB, ELISA |
PTGDR2 Proteins
PTGDR2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP744318RA1 CSB-EP744318RA1 CSB-BP744318RA1 CSB-MP744318RA1 CSB-EP744318RA1-B |
Recombinant Rat Prostaglandin D2 receptor 2 (Ptgdr2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF744318RA | Recombinant Rat Prostaglandin D2 receptor 2 (Ptgdr2) | in vitro E.coli expression system |
PTGDR2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP896745HU1 CSB-EP896745HU1 CSB-BP896745HU1 CSB-MP896745HU1 CSB-EP896745HU1-B |
Recombinant Human Prostaglandin D2 receptor 2 (PTGDR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF896745HU | Recombinant Human Prostaglandin D2 receptor 2 (PTGDR2) | in vitro E.coli expression system |
