PYCARD
PYCARD，全稱為PYD和CARD結構域包含蛋白，常見別名有ASC、CARD5、TMS1、hASC等，是一類廣泛存在于細胞質中的保守接頭蛋白，核心參與固有免疫與細胞凋亡相關的調控過程。它通過自身特殊結構連接相關分子，促進炎癥小體組裝與活化，助力炎癥因子釋放，同時參與細胞凋亡調控，維持機體正常免疫穩態與細胞生理平衡，在多種組織器官中均有表達。
PYCARD異常與多種疾病密切相關，既涉及穆克勒-韋爾斯綜合征、家族地中海熱等自身免疫性疾病，也與乳腺癌、肺癌、卵巢癌等惡性腫瘤相關，同時在抗中性粒細胞胞質抗體相關性腎炎中可作為高效診斷標志物。目前相關研究主要集中在其診斷價值挖掘與靶向干預探索，針對其調控的炎癥相關過程，候選抑制劑正處于臨床前驗證階段，為相關炎癥性疾病與腫瘤的治療提供了新的潛在方向。
熱銷產品
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PYCARD Antibody (CSB-PA000940)
驗證數據
Western Blot analysis of 823 293T cells using ASC Polyclonal Antibody
Human Apoptosis-associated speck-like protein containing a CARD(PYCARD) ELISA kit (CSB-EL019114HU)
驗證數據
貨號：CSB-EL019114HU
規格：96T/48T
靈敏度：3.9 pg/mL
檢測范圍：15.6 pg/mL-1000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
PYCARD Antibodies
PYCARD for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA019114GA01HU | PYCARD Antibody | Human | ELISA,WB,IHC |
| CSB-PA000940 | PYCARD Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA890936LA01HU | PYCARD Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA890936LB01HU | PYCARD Antibody, HRP conjugated | Human | ELISA |
| CSB-PA890936LC01HU | PYCARD Antibody, FITC conjugated | Human | |
| CSB-PA890936LD01HU | PYCARD Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA057690A0HU | PYCARD Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF |
PYCARD Proteins
PYCARD Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP810219BO CSB-EP810219BO CSB-BP810219BO CSB-MP810219BO CSB-EP810219BO-B |
Recombinant Bovine Apoptosis-associated speck-like protein containing a CARD (PYCARD) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PYCARD Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-BP861664MO CSB-MP861664MO CSB-EP861664MO-B |
Recombinant Mouse Apoptosis-associated speck-like protein containing a CARD (Pycard) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP861664MO | Recombinant Mouse Apoptosis-associated speck-like protein containing a CARD (Pycard) | E.coli |
PYCARD Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP862308DIL CSB-EP862308DIL CSB-BP862308DIL CSB-MP862308DIL CSB-EP862308DIL-B |
Recombinant Danio rerio Apoptosis-associated speck-like protein containing a CARD (pycard) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PYCARD Proteins for Homo sapiens (Human)
PYCARD ELISA Kit
PYCARD ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL019114HU | Human Apoptosis-associated speck-like protein containing a CARD(PYCARD) ELISA kit | serum, plasma, tissue homogenates | 3.9 pg/mL |
PYCARD ELISA Kit for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL019114MO | Mouse Apoptosis-associated speck-like protein containing a CARD(PYCARD) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 1.95 pg/mL |
