RB1
RB1，全稱為視網(wǎng)膜母細胞瘤蛋白1，常用別名pRb、抑癌蛋白Rb。它是人體重要的抑癌蛋白，廣泛分布于各類體細胞細胞核中，能夠約束細胞異常分裂增殖，穩(wěn)定細胞周期進程，阻止細胞無序惡性生長，是維持機體細胞正常生長秩序的關(guān)鍵分子。
RB1功能失活或缺失會大幅提升腫瘤發(fā)生風(fēng)險，是遺傳性視網(wǎng)膜母細胞瘤的致病核心，同時也與骨肉瘤、小細胞肺癌、乳腺癌等多種惡性腫瘤密切相關(guān)。目前臨床主要通過篩查、手術(shù)及放化療干預(yù)，靶向恢復(fù)RB1功能的小分子藥物、基因修復(fù)療法仍處于臨床前研究階段，通過重建抑癌能力抑制腫瘤進展，為相關(guān)惡性腫瘤治療提供全新潛在方案。
熱銷產(chǎn)品
Recombinant Human Retinoblastoma-associated protein (RB1), partial (CSB-EP019386HU2)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
RB1 Recombinant Monoclonal Antibody (CSB-RA931443A0HU)
驗證數(shù)據(jù)
Flow cytometric analysis of Phospho-Retinoblastoma (S807) expression in HAP-1 cells using Phospho-Retinoblastoma (S807) antibody. Green, isotype control; red, Phospho-Retinoblastoma (S807).
Immunocytochemical staining of HAP-1 cells with phospho-retinoblastoma (S807) antibody. Nuclei were stained blue with DAPI; Phospho-retinoblastoma (S807) was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar: 20 μm.
Western blotting analysis using phospho-retinoblastoma (S807) antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with phospho-retinoblastoma (S807) antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
RB1 Antibodies
RB1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA019386GA01HU | RB1 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA201739 | Phospho-RB1 (Ser795) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA193785 | Phospho-RB1 (Ser807) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA133410 | Phospho-RB1 (Ser780) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA990932 | RB1 (Ab-795) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA445358 | RB1 (Ab-807) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA095986 | RB1 (Ab-780) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA582717 | Phospho-RB1 (Ser608) Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA036254 | RB1 (Ab-608) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA237047 | Phospho-RB1 (Thr826) Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA019386ESR2HU | RB1 Antibody | Human | ELISA, IHC |
| CSB-PA000616 | Phospho-RB1 (S780) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA000617 | Phospho-RB1 (S807) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA003947 | RB1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA003948 | RB1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA040164 | Phospho-RB1 (S795) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA040165 | Phospho-RB1 (S811) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA040166 | Phospho-RB1 (T826) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA040167 | Phospho-RB1 (S608) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA040168 | Phospho-RB1 (S612) Antibody | Human | IHC, ELISA |
| CSB-PA040169 | Phospho-RB1 (S788) Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA040170 | Phospho-RB1 (T821) Antibody | Human,Mouse,Rat | IHC, IF, ELISA |
| CSB-PA040171 | Phospho-RB1 (S249) Antibody | Human,Mouse,Rat | IF, ELISA |
| CSB-PA040172 | RB1 Antibody | Human,Mouse,Rat | IHC, IF, ELISA |
| CSB-PA040173 | RB1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA040174 | RB1 Antibody | Human,Mouse,Rat | IHC, IF, ELISA |
| CSB-PA040176 | RB1 Antibody | Human,Mouse,Rat | IHC, IF, ELISA |
| CSB-PA040177 | RB1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA232358 | RB1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-RA019386A807phHU | Phospho-RB1 (S807) Recombinant Monoclonal Antibody | Human | ELISA, IF |
| CSB-RA019386A780phHU | Phospho-RB1 (S780) Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF, IP |
| CSB-RA931443A0HU | RB1 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, FC, ICC |
| CSB-RA870271A0HU | RB1 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, FC, ICC |
RB1 Proteins
RB1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP019386MO CSB-EP019386MO CSB-BP019386MO CSB-MP019386MO CSB-EP019386MO-B |
Recombinant Mouse Retinoblastoma-associated protein (Rb1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RB1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP019386RA CSB-EP019386RA CSB-BP019386RA CSB-MP019386RA CSB-EP019386RA-B |
Recombinant Rat Retinoblastoma-associated protein (Rb1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-RP155294r(A3) | Recombinant Rat Retinoblastoma-associated protein (Rb1), partial | E.coli |
RB1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP019386HU CSB-BP019386HU CSB-MP019386HU CSB-EP019386HU-B |
Recombinant Human Retinoblastoma-associated protein (RB1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP019386HU2 | Recombinant Human Retinoblastoma-associated protein (RB1), partial | E.coli |
| CSB-EP019386HU | Recombinant Human Retinoblastoma-associated protein (RB1), partial | E.coli |
RB1 Proteins for Cocos nucifera (Coconut)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP814119CMW CSB-EP814119CMW CSB-BP814119CMW CSB-MP814119CMW CSB-EP814119CMW-B |
Recombinant Cocos nucifera Retinoblastoma-related protein (Rb1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RB1 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP856183CH CSB-EP856183CH CSB-BP856183CH CSB-MP856183CH CSB-EP856183CH-B |
Recombinant Chicken Retinoblastoma-associated protein (RB1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RB1 Proteins for Nicotiana tabacum (Common tobacco)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP871200NHE CSB-EP871200NHE CSB-BP871200NHE CSB-MP871200NHE CSB-EP871200NHE-B |
Recombinant Nicotiana tabacum Retinoblastoma-related protein 1 (RB1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
