RIGI
RIGI，全稱為維甲酸誘導基因I蛋白，常被簡稱為RIG-I，另有DDX58這一關聯名稱。作為先天免疫中的核心分子，它能敏銳識別入侵細胞的病毒RNA，啟動機體的抗病毒防御反應。當感知到病毒核酸信號后，它會與細胞內的MAVS等分子協作，推動干擾素和炎癥因子的釋放，幫助清除病毒病原體。
RIGI功能狀態與多種疾病密切相關：流感、乙肝、新冠等病毒感染時，其激活程度直接影響免疫應答的強度；若活性異常升高，還可能誘發自身免疫性炎癥疾病。在藥物研發領域，針對RIG-I的調節劑是研究熱點，小分子激動劑可增強其抗病毒能力，有望用于慢性病毒性肝炎的治療，部分候選藥物已進入臨床前或早期臨床試驗階段，為相關疾病的干預提供了新方向。
熱銷產品
Recombinant?Human?Antiviral?innate?immune?response?receptor?RIG-I (RIGI), partial (CSB-EP006638HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
DDX58 Recombinant Monoclonal Antibody (CSB-RA207378A0HU)
驗證數據
IHC image of CSB-RA207378A0HU diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
驗證數據
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cells, Primary antibody: CSB-PA652501(DDX58 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
RIGI Antibodies
RIGI for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA006638LA01HU | DDX58 Antibody | Human | ELISA |
| CSB-PA006638GA01HU | DDX58 Antibody | Human | ELISA,WB,IF |
| CSB-PA695560 | DDX58 Antibody | Human | ELISA,WB,IHC |
| CSB-PA652501 | DDX58 Antibody | Human | ELISA,WB |
| CSB-RA207378A0HU | DDX58 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
RIGI Proteins
RIGI Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006638HU CSB-BP006638HU CSB-MP006638HU CSB-EP006638HU-B |
Recombinant?Human?Antiviral?innate?immune?response?receptor?RIG-I (RIGI), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP006638HU | Recombinant?Human?Antiviral?innate?immune?response?receptor?RIG-I (RIGI), partial | E.coli |
