RNASEL
核糖核酸酶L（RNASEL，又稱RNase L）是人體免疫系統(tǒng)里的重要蛋白。當(dāng)病毒入侵時，它會被激活，通過切割病毒的RNA來阻止病毒復(fù)制，同時還能調(diào)節(jié)細胞的生長和凋亡，維持身體的免疫平衡。此外，它也參與炎癥反應(yīng)的調(diào)控，幫助身體應(yīng)對感染。
在疾病方面，RNASEL的基因變異和遺傳性前列腺癌的風(fēng)險相關(guān)，部分攜帶突變的人更容易患上這種癌癥；它還和丙肝、HIV等慢性病毒感染的病程有關(guān)，活性異常可能導(dǎo)致病毒難以清除或引發(fā)過度免疫損傷。藥物研發(fā)上，針對它的小分子調(diào)節(jié)劑正在研究：激活劑有望增強抗病毒能力，用于治療難治性病毒感染；抑制劑則可能緩解因它過度激活導(dǎo)致的自身免疫病，但目前多數(shù)候選藥物還在臨床前或早期試驗階段，尚未普及到臨床治療中。
熱銷產(chǎn)品
Recombinant Human 2-5A-dependent ribonuclease (RNASEL) (CSB-EP313223HUe0)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
RNASEL Antibodies
RNASEL for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA313223LD01HU | RNASEL Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA313223LC01HU | RNASEL Antibody, FITC conjugated | Human | |
| CSB-PA313223LB01HU | RNASEL Antibody, HRP conjugated | Human | ELISA |
| CSB-PA313223LA01HU | RNASEL Antibody | Human | ELISA, IHC |
RNASEL Proteins
RNASEL Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP313223HU CSB-BP313223HU CSB-MP313223HU CSB-EP313223HU-B |
Recombinant Human 2-5A-dependent ribonuclease (RNASEL) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP313223HU1 | Recombinant Human 2-5A-dependent ribonuclease (RNASEL), partial | E.coli |
| CSB-EP313223HU | Recombinant Human 2-5A-dependent ribonuclease (RNASEL) | E.coli |
| CSB-EP313223HUe0 | Recombinant Human 2-5A-dependent ribonuclease (RNASEL) | E.coli |
| CSB-BP313223HU2 | Recombinant Human 2-5A-dependent ribonuclease (RNASEL), partial | Baculovirus |
RNASEL Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP313237MO CSB-EP313237MO CSB-BP313237MO CSB-MP313237MO CSB-EP313237MO-B |
Recombinant Mouse 2-5A-dependent ribonuclease (Rnasel), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
