RPA1
RPA1，全稱為復(fù)制蛋白A1，常用別名有復(fù)制因子A蛋白1、RF?A 70kDa亞基。它是細(xì)胞核內(nèi)重要的單鏈DNA結(jié)合蛋白，在DNA復(fù)制、損傷修復(fù)與染色體穩(wěn)定維持中承擔(dān)核心作用，能夠結(jié)合并保護(hù)單鏈DNA結(jié)構(gòu)，保障遺傳信息準(zhǔn)確傳遞，對(duì)細(xì)胞正常分裂與基因組穩(wěn)定意義重大。
RPA1功能異常或表達(dá)失調(diào)，會(huì)導(dǎo)致基因組穩(wěn)定性下降，顯著提升多種惡性腫瘤的發(fā)生風(fēng)險(xiǎn)，尤其與卵巢癌、結(jié)直腸癌、白血病等疾病密切相關(guān)。由于該蛋白在腫瘤細(xì)胞增殖中高度活躍，已成為抗腫瘤藥物研發(fā)的重要靶點(diǎn)。目前針對(duì)RPA1的小分子抑制劑正處于臨床前研究階段，通過(guò)干擾其DNA結(jié)合能力抑制腫瘤增殖，為靶向治療提供了新的潛在方向。
RPA1 Antibodies
RPA1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA020088GA01HU | RPA1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA018322GA01HU | POLR1A Antibody | Human | ELISA,WB |
| CSB-PA020088LA01HU | RPA1 Antibody | Human, Mouse, Rat | ELISA, WB, IHC |
| CSB-PA020088LB01HU | RPA1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA020088LC01HU | RPA1 Antibody, FITC conjugated | Human | |
| CSB-PA020088LD01HU | RPA1 Antibody, Biotin conjugated | Human | ELISA |
RPA1 Proteins
RPA1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP020088HU CSB-BP020088HU CSB-MP020088HU CSB-EP020088HU-B |
Recombinant Human Replication protein A 70 kDa DNA-binding subunit (RPA1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP018322HU CSB-EP018322HU CSB-BP018322HU CSB-MP018322HU CSB-EP018322HU-B |
Recombinant Human DNA-directed RNA polymerase I subunit RPA1 (POLR1A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP020088HU | Recombinant Human Replication protein A 70 kDa DNA-binding subunit (RPA1) | E.coli |
RPA1 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP020088XBE CSB-EP020088XBE CSB-BP020088XBE CSB-MP020088XBE CSB-EP020088XBE-B |
Recombinant Xenopus laevis Replication protein A 70 kDa DNA-binding subunit (rpa1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RPA1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP018322SXV CSB-EP018322SXV CSB-BP018322SXV CSB-MP018322SXV CSB-EP018322SXV-B |
Recombinant Schizosaccharomyces pombe DNA-directed RNA polymerase I subunit rpa1 (rpa1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RPA1 Proteins for Euplotes octocarinatus
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP018322EPO CSB-EP018322EPO CSB-BP018322EPO CSB-MP018322EPO CSB-EP018322EPO-B |
Recombinant DNA-directed RNA polymerase I subunit RPA1 (RPA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RPA1 Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP020088PYX CSB-EP020088PYX CSB-BP020088PYX CSB-MP020088PYX CSB-EP020088PYX-B |
Recombinant Pongo abelii Replication protein A 70 kDa DNA-binding subunit (RPA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RPA1 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP020088CH CSB-EP020088CH CSB-BP020088CH CSB-MP020088CH CSB-EP020088CH-B |
Recombinant Chicken Replication protein A 70 kDa DNA-binding subunit (RPA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RPA1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP020088DIL CSB-EP020088DIL CSB-BP020088DIL CSB-MP020088DIL CSB-EP020088DIL-B |
Recombinant Danio rerio Replication protein A 70 kDa DNA-binding subunit (rpa1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RPA1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP020088MO CSB-EP020088MO CSB-BP020088MO CSB-MP020088MO CSB-EP020088MO-B |
Recombinant Mouse Replication protein A 70 kDa DNA-binding subunit (Rpa1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RPA1 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP020088XBF CSB-EP020088XBF CSB-BP020088XBF CSB-MP020088XBF CSB-EP020088XBF-B |
Recombinant Xenopus tropicalis Replication protein A 70 kDa DNA-binding subunit (rpa1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RPA1 Proteins for Crithidia fasciculata
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP631524DXW CSB-EP631524DXW CSB-BP631524DXW CSB-MP631524DXW CSB-EP631524DXW-B |
Recombinant Replication factor A 51 kDa subunit (RPA1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
