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SCN2A

SCN2A,全稱為Sodium channel protein type 2 subunit alpha,常見別名包括Nav1.2、HBSCII等。該蛋白屬于電壓門控性鈉通道α亞基2,主要在腦內表達,可與鈉離子通道β亞基組成電壓門控性鈉通道,參與神經元電信號的傳遞。SCN2A蛋白與癲癇、自閉癥等神經發育障礙密切相關,其突變可導致神經元過度興奮或功能喪失,從而引發癲癇發作或自閉癥癥狀。目前,針對SCN2A相關疾病的治療尚無特效藥物,但已有研究利用患者來源的人腦類器官模型進行藥物篩選,發現卡馬西平等抗癲癇藥對SCN2A突變體的效果各異,為精準治療提供了新的思路。此外,個性化反義寡核苷酸療法也在探索中,旨在通過降低SCN2A突變體的表達來改善患者癥狀。

熱銷產品

SCN2A Antibody (CSB-PA937791)

驗證數據

CSB-PA937791

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA937791(SCN2A Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)

CSB-PA937791

The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA937791(SCN2A Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)

SCN2A Antibodies

SCN2A for Homo sapiens (Human)

SCN2A Proteins

SCN2A Proteins for Homo sapiens (Human)



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