SINHCAF

SINHCAF，即SIN3-HDAC復合體相關因子，別名FAM60A、TERA。這是一種在人類細胞中發(fā)現(xiàn)的蛋白質(zhì)，參與調(diào)控基因表達。SINHCAF是組蛋白去乙酰化酶復合體的組分之一，通過與SIN3A和HDAC1等蛋白相互作用，促進組蛋白去乙酰化，從而抑制基因的表達。在斑馬魚中，SINHCAF對于原始生殖細胞（PGC）的形成至關重要，其敲除會導致PGC數(shù)量減少，影響性別比例，而過表達則會增加PGC數(shù)量，并傾向于雌性。此外，SINHCAF還參與負向調(diào)控細胞遷移，是Sin3復合體的一部分，對維持胚胎干細胞的快速增殖潛力和防止過早的細胞系分化至關重要。這些功能表明SINHCAF在細胞命運決定和發(fā)育過程中扮演著重要角色。

熱銷產(chǎn)品

Recombinant Human SIN3-HDAC complex-associated factor (SINHCAF) (Active) (CSB-EP882059HUe0)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized LCN2 at 2 μg/ml can bind human SINHCAF, the EC₅₀ of human SINHCAF protein is 31.54-38.59 μg/ml.

SINHCAF Antibody

SINHCAF Protein

SINHCAF Antibodies

SINHCAF for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應性	應用類型
CSB-PA882059LA01HU	FAM60A Antibody	Human	ELISA, IHC
CSB-PA882059LD01HU	FAM60A Antibody, Biotin conjugated	Human	ELISA

SINHCAF Proteins

SINHCAF Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP882059HU CSB-EP882059HU CSB-BP882059HU CSB-MP882059HU CSB-EP882059HU-B	Recombinant Human Protein FAM60A (FAM60A)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP882059HUe0	Recombinant Human SIN3-HDAC complex-associated factor (SINHCAF) (Active)	E.coli