SLC39A5
SLC39A5，全稱為溶質(zhì)載體家族39成員5，常用別名鋅轉(zhuǎn)運(yùn)蛋白SLC39A5。它是細(xì)胞膜上的鋅離子轉(zhuǎn)運(yùn)蛋白，廣泛表達(dá)于人體各類組織，參與細(xì)胞內(nèi)鋅離子攝取、轉(zhuǎn)運(yùn)及穩(wěn)態(tài)調(diào)控，鋅離子作為多種酶的輔酶，對細(xì)胞代謝、增殖、分化及免疫功能維持具有重要意義。 SLC39A5功能異常與鋅代謝紊亂及多種疾病相關(guān)，表達(dá)不足會導(dǎo)致細(xì)胞內(nèi)鋅缺乏，影響酶活性及免疫功能，與發(fā)育遲緩、免疫缺陷相關(guān)；異常高表達(dá)則會導(dǎo)致鋅過量蓄積，與肺癌、乳腺癌等腫瘤相關(guān)，促進(jìn)腫瘤細(xì)胞增殖。目前SLC39A5調(diào)節(jié)劑處于臨床前研究階段，通過調(diào)控鋅轉(zhuǎn)運(yùn)，為鋅代謝異常疾病及腫瘤提供治療方向。
熱銷產(chǎn)品
Recombinant Human Zinc transporter ZIP5 (SLC39A5) (CSB-CF747773HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
SLC39A5 Antibody (CSB-PA900358)
驗(yàn)證數(shù)據(jù)
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Hepg2 cells, Primary antibody: CSB-PA900358(SLC39A5 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
SLC39A5 Antibodies
SLC39A5 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA900358 | SLC39A5 Antibody | Human | ELISA,WB |
SLC39A5 Proteins
SLC39A5 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP747773HU1 CSB-EP747773HU1 CSB-BP747773HU1 CSB-MP747773HU1 CSB-EP747773HU1-B |
Recombinant Human Zinc transporter ZIP5 (SLC39A5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF747773HU | Recombinant Human Zinc transporter ZIP5 (SLC39A5) | in vitro E.coli expression system |
