Siglec-12
Siglec-12，全稱為唾液酸結合免疫球蛋白樣凝集素 12，常用別名 SIGLEC12。它是髓系細胞表面抑制性受體，主要表達于巨噬細胞、單核細胞，結合唾液酸配體后調控免疫細胞活化狀態，參與全身炎癥平衡、組織免疫穩態調節。 Siglec-12 異常表達與慢性炎癥、代謝性疾病、乳腺癌、結直腸癌等惡性腫瘤高度相關，會顯著促進腫瘤微環境免疫抑制，加速腫瘤進展轉移。目前靶向 Siglec-12 阻斷抗體處于臨床前研發階段，通過逆轉免疫抑制狀態增強抗腫瘤效果，是新一代腫瘤免疫治療重點開發靶點。
熱銷產品
SIGLEC12 Antibody (CSB-PA812859)
驗證數據
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA812859(SIGLEC12 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 8%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA812859(SIGLEC12 Antibody) at dilution 1/500 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute
Siglec-12 Antibodies
Siglec-12 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA812859 | SIGLEC12 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA955877 | SIGLEC12 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA836278ESR1HU | SIGLEC12 Antibody | Human | ELISA, IHC |
Siglec-12 Proteins
Siglec-12 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP836278HU CSB-EP836278HU CSB-BP836278HU CSB-MP836278HU CSB-EP836278HU-B |
Recombinant Human Sialic acid-binding Ig-like lectin 12 (SIGLEC12), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
