TEAD2
TEAD2，全稱為轉(zhuǎn)錄增強(qiáng)關(guān)聯(lián)域蛋白2，常見別名包括TEF-4、ETF等。它是細(xì)胞內(nèi)重要的轉(zhuǎn)錄調(diào)控分子，通過與特定蛋白結(jié)合調(diào)節(jié)基因表達(dá)，參與細(xì)胞生長、增殖和組織發(fā)育的過程。在正常細(xì)胞中，它會(huì)和Hippo路徑里的分子相互作用，維持細(xì)胞增殖與凋亡的平衡；一旦這種平衡被打破，可能導(dǎo)致細(xì)胞過度生長，增加疾病風(fēng)險(xiǎn)。
研究顯示，TEAD2的異?；钚耘c胃癌、肺癌、乳腺癌等多種腫瘤密切相關(guān)，其表達(dá)水平升高往往會(huì)促進(jìn)腫瘤細(xì)胞的增殖和擴(kuò)散。目前針對該蛋白的藥物研發(fā)已取得初步進(jìn)展，一些小分子抑制劑被設(shè)計(jì)用于阻斷其功能，部分候選藥物進(jìn)入早期臨床試驗(yàn)階段，有望為相關(guān)腫瘤治療提供新的方向。
熱銷產(chǎn)品
Recombinant Human Transcriptional enhancer factor TEF-4 (TEAD2), partial (CSB-EP613597HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗(yàn)證數(shù)據(jù)
Western Blot analysis of mouse-brain cells using TEF-4 Polyclonal Antibody
TEAD2 Antibodies
TEAD2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA070034 | TEAD2 Antibody | Human,Mouse | WB, IHC, IF, ELISA |
TEAD2 Proteins
TEAD2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023364MO CSB-EP023364MO CSB-BP023364MO CSB-MP023364MO CSB-EP023364MO-B |
Recombinant Mouse Transcriptional enhancer factor TEF-4 (Tead2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TEAD2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP613597HU1 CSB-BP613597HU1 CSB-MP613597HU1 CSB-EP613597HU1-B |
Recombinant Human Transcriptional enhancer factor TEF-4 (TEAD2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP613597HU1 | Recombinant Human Transcriptional enhancer factor TEF-4 (TEAD2), partial | E.coli |
| CSB-EP613597HU2 | Recombinant Human Transcriptional enhancer factor TEF-4 (TEAD2), partial | E.coli |
| CSB-EP613597HU2c7 | Recombinant Human Transcriptional enhancer factor TEF-4 (TEAD2), partial | E.coli |
| CSB-EP613597HU2g5 | Recombinant Human Transcriptional enhancer factor TEF-4 (TEAD2), partial | E.coli |
| CSB-EP613597HU2d7 | Recombinant Human Transcriptional enhancer factor TEF-4 (TEAD2), partial | E.coli |
