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TGFBR2

TGFBR2,即轉化生長因子β受體2,別名TGFβR-II、TGFβRII。它是一種跨膜蛋白,由TGFBR2基因編碼,主要在細胞表面發揮作用。TGFBR2的作用機制涉及與轉化生長因子β(TGF-β)家族配體結合,激活其內在的絲氨酸/蘇氨酸激酶活性,進而磷酸化并激活Smad蛋白,這些Smad蛋白隨后轉移到細胞核,調控下游基因的表達。TGFBR2在細胞增殖、分化、遷移和凋亡等過程中發揮關鍵作用,影響組織發育、免疫調節、纖維化和腫瘤發展等生物學過程。

熱銷產品

Recombinant Human TGF-beta receptor type-2 (TGFBR2), partial (Active) (CSB-MP023452HU2)

驗證數據

CSB-MP023452HU2

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP023452HU2

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TGFB3 (CSB-MP023449HU2) at 2 μg/ml can bind Human TGFBR2. The EC50 is 6.173-7.152 ng/mL.

CSB-MP023452HU2

Activity
Human TGFBR2 captured on Protein A Chip can bind Recombinant Human TGFB3 (CSB-MP023449HU2) with an affinity constant of 1.92 nM as detected by MetaSPR Assay (WeSPRTM 200).

CSB-MP023452HU2

The purity of TGFBR2 was greater than 90% as determined by SEC-HPLC

Recombinant Human TGF-beta receptor type-2 (TGFBR2), partial (CSB-EP023452HU1)

驗證數據

CSB-EP023452HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TGFBR2 Antibody (CSB-PA023452LA01HU)

驗證數據

CSB-PA023452LA01HU

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA023452LA01HU at dilution of 1:100

CSB-PA023452LA01HU

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA023452LA01HU at dilution of 1:100

CSB-PA023452LA01HU

Immunofluorescent analysis of MCF-7 cells using CSB-PA023452LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

TGFBR2 Antibodies

TGFBR2 for Homo sapiens (Human)

TGFBR2 Proteins

TGFBR2 Proteins for Rattus norvegicus (Rat)

TGFBR2 Proteins for Sus scrofa (Pig)

TGFBR2 Proteins for Mus musculus (Mouse)

TGFBR2 Proteins for Gallus gallus (Chicken)

TGFBR2 Proteins for Homo sapiens (Human)

TGFBR2 ELISA Kit

TGFBR2 ELISA Kit for Homo sapiens (Human)



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