TNFSF4
TNFSF4，全稱為腫瘤壞死因子超家族成員4，常見別名包括OX40配體、CD252。它是免疫應答中的關鍵分子，能與免疫細胞表面的OX40受體結合，推動T細胞的活化與持續(xù)增殖，還能調(diào)節(jié)細胞因子分泌，影響免疫反應的強度和時長。
TNFSF4異常表達與多種疾病相關：在類風濕關節(jié)炎、系統(tǒng)性紅斑狼瘡等自身免疫病中，它可能過度激活免疫細胞，加重炎癥；在腫瘤里，部分腫瘤細胞會利用它抑制免疫細胞的殺傷作用，幫助自身逃避免疫監(jiān)視。目前針對該蛋白的藥物研發(fā)已有進展，比如阻斷其與受體結合的抗體，正探索用于治療自身免疫??；激活該通路的激動劑則有望增強抗腫瘤免疫，部分候選藥已進入臨床試驗，為相關疾病治療提供新方向。
熱銷產(chǎn)品
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse Tnfsf4 at 4 μg/ml can bind Mouse Tnfrsf4 (CSB-MP023981MOd9) . The EC50 is 3.581-4.060 ng/mL.
Activity
Mouse Tnfrsf4 (CSB-MP023981MOd9) captured on Protein A Chip can bind Recombinant Mouse Tnfsf4 with an affinity constant of 0.438 nM as detected by MetaSPR Assay (WeSPRTM 200).
TNFSF4 Antibody (CSB-PA006280)
驗證數(shù)據(jù)
Western Blot analysis of KB cells using Ox40L Polyclonal Antibody
Western Blot analysis of KB cells using Ox40L Polyclonal Antibody
TNFSF4 Antibodies
TNFSF4 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA006280 | TNFSF4 Antibody | Human | WB, ELISA |
| CSB-PA060031 | TNFSF4 Antibody | Human | IF, ELISA |
| CSB-PA920694 | TNFSF4 Antibody | Human | ELISA,IHC |
TNFSF4 Proteins
TNFSF4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023994HU1 CSB-EP023994HU1 CSB-BP023994HU1 CSB-EP023994HU1-B |
Recombinant Human Tumor necrosis factor ligand superfamily member 4 (TNFSF4), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF023994HU | Recombinant Human Tumor necrosis factor ligand superfamily member 4 (TNFSF4) | in vitro E.coli expression system |
| CSB-AP005261HU | Recombinant Human Tumor necrosis factor ligand superfamily member 4 (TNFSF4), partial (Active) | Mammalian cell |
| CSB-MP023994HU1 | Recombinant Human Tumor necrosis factor ligand superfamily member 4 (TNFSF4), partial | Mammalian cell |
| CSB-MP023994HU1c9 | Recombinant Human Tumor necrosis factor ligand superfamily member 4 (TNFSF4), partial | Mammalian cell |
| CSB-MP023994HU1-B | Recombinant Human Tumor necrosis factor ligand superfamily member 4 (TNFSF4), partial, Biotinylated | Mammalian cell |
| CSB-MP023994HU1b0 | Recombinant Human Tumor necrosis factor ligand superfamily member 4 (TNFSF4), partial | Mammalian cell |
TNFSF4 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023994MO1 CSB-EP023994MO1 CSB-BP023994MO1 CSB-EP023994MO1-B |
Recombinant Mouse Tumor necrosis factor ligand superfamily member 4 (Tnfsf4), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF023994MO | Recombinant Mouse Tumor necrosis factor ligand superfamily member 4 (Tnfsf4) | in vitro E.coli expression system |
TNFSF4 Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP023994RB1-B |
Recombinant Rabbit Tumor necrosis factor ligand superfamily member 4 (TNFSF4), partial | In Vivo Biotinylation in E.coli |
| CSB-CF023994RB | Recombinant Rabbit Tumor necrosis factor ligand superfamily member 4 (TNFSF4) | in vitro E.coli expression system |
| CSB-BP023994RB1 | Recombinant Rabbit Tumor necrosis factor ligand superfamily member 4 (TNFSF4), partial | Baculovirus |
| CSB-MP023994RB1 | Recombinant Rabbit Tumor necrosis factor ligand superfamily member 4 (TNFSF4), partial | Mammalian cell |
| CSB-EP023994RB1 | Recombinant Rabbit Tumor necrosis factor ligand superfamily member 4 (TNFSF4), partial | E.coli |
| CSB-YP023994RB1 | Recombinant Rabbit Tumor necrosis factor ligand superfamily member 4 (TNFSF4), partial | Yeast |
TNFSF4 ELISA Kit
TNFSF4 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E12752h | Human soluble OX40L (sOX40L) ELISA kit | serum, plasma, tissue homogenates | 0.039 ng/mL |
TNFSF4 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL023994MO | Mouse Tumor necrosis factor ligand superfamily member 4(TNFSF4) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 3.9 pg/mL |
