Tnfrsf4
Tnfrsf4，全稱為腫瘤壞死因子受體超家族成員4，常用別名OX40。它是細胞膜表面的免疫調節受體，主要表達于T細胞、B細胞等免疫細胞，參與免疫細胞活化、增殖、存活調控，維持機體免疫穩態，在抗腫瘤免疫、自身免疫病中發揮重要作用。 Tnfrsf4異常表達與自身免疫病、腫瘤密切相關，異?；罨瘯龠M免疫細胞過度增殖，誘發自身免疫病；同時在腫瘤中異常表達，可增強抗腫瘤免疫應答，抑制腫瘤生長。目前Tnfrsf4激動劑與抑制劑處于臨床前及早期臨床研究階段，通過調控免疫活性，為自身免疫病及腫瘤免疫治療提供新型思路。
熱銷產品
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse Tnfsf4 (CSB-MP023994MO1b0) at 4 μg/ml can bind Mouse Tnfrsf4. The EC50 is 3.581-4.060 ng/mL.
Activity
Mouse Tnfrsf4 captured on Protein A Chip can bind Recombinant Mouse Tnfsf4 (CSB-MP023994MO1b0) with an affinity constant of 0.438 nM as detected by MetaSPR Assay (WeSPRTM 200).
Tnfrsf4 Antibodies
Tnfrsf4 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA023981GA01HU | TNFRSF4 Antibody | Human | ELISA,WB |
| CSB-PA006263 | TNFRSF4 Antibody | Human | WB, ELISA |
| CSB-PA010555 | TNFRSF4 Antibody | Human,Mouse,Rat | WB, ELISA, WB 1:500-1:2000, ELISA:1:10000 |
| CSB-PA081622 | TNFRSF4 Antibody | Human | ELISA,WB |
| CSB-RA023981MA1HU | TNFRSF4 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
Tnfrsf4 for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA023981HA01MO | Tnfrsf4 Antibody | Mouse | ELISA |
| CSB-PA023981HD01MO | Tnfrsf4 Antibody, Biotin conjugated | Mouse | ELISA |
| CSB-PA023981HC01MO | Tnfrsf4 Antibody, FITC conjugated | Mouse | |
| CSB-PA023981HB01MO | Tnfrsf4 Antibody, HRP conjugated | Mouse | ELISA |
Tnfrsf4 Proteins
Tnfrsf4 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP023981RA1 CSB-EP023981RA1 CSB-BP023981RA1 CSB-MP023981RA1 CSB-EP023981RA1-B |
Recombinant Rat Tumor necrosis factor receptor superfamily member 4 (Tnfrsf4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF023981RA | Recombinant Rat Tumor necrosis factor receptor superfamily member 4 (Tnfrsf4) | in vitro E.coli expression system |
Tnfrsf4 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP023981HU1 CSB-EP023981HU1 CSB-BP023981HU1 CSB-EP023981HU1-B |
Recombinant Human Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF023981HU | Recombinant Human Tumor necrosis factor receptor superfamily member 4 (TNFRSF4) | in vitro E.coli expression system |
| CSB-AP005241HU | Recombinant Human Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), partial (Active) | Mammalian cell |
| CSB-AP005251HU | Recombinant Human Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), partial (Active) | Mammalian cell |
| CSB-MP023981HU1 | Recombinant Human Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), partial | Mammalian cell |
Tnfrsf4 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP023981MO CSB-BP023981MO CSB-EP023981MO-B |
Recombinant Mouse Tumor necrosis factor receptor superfamily member 4 (Tnfrsf4), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP023981MO | Recombinant Mouse Tumor necrosis factor receptor superfamily member 4 (Tnfrsf4), partial | E.coli |
| CSB-CF023981MO | Recombinant Mouse Tumor necrosis factor receptor superfamily member 4 (Tnfrsf4) | in vitro E.coli expression system |
| CSB-AP005321MO | Recombinant Mouse Tumor necrosis factor receptor superfamily member 4 (Tnfrsf4), partial (Active) | Mammalian cell |
| CSB-AP005331MO | Recombinant Mouse Tumor necrosis factor receptor superfamily member 4 (Tnfrsf4), partial (Active) | Mammalian cell |
| CSB-MP023981MO | Recombinant Mouse Tumor necrosis factor receptor superfamily member 4 (Tnfrsf4) | Mammalian cell |
| CSB-MP023981MOd9 | Recombinant Mouse Tumor necrosis factor receptor superfamily member 4 (Tnfrsf4), partial (Active) | Mammalian cell |
