U2AF2
U2AF2，全稱為U2小核RNA輔助因子2，常用別名是U2AF65。它在細(xì)胞內(nèi)扮演著RNA剪接的“向?qū)А苯巧芫珳?zhǔn)識(shí)別信使RNA前體上的特定區(qū)域，協(xié)助剪接體完成基因片段的正確拼接，保證蛋白質(zhì)合成的信息傳遞準(zhǔn)確無誤。U2AF2功能異常會(huì)打亂正常的基因表達(dá)過程，與多種疾病關(guān)聯(lián)緊密——比如急性髓系白血病患者中它的表達(dá)量常明顯升高，干擾細(xì)胞的正常生長調(diào)控；在肺癌、結(jié)直腸癌等實(shí)體腫瘤里，它也參與推動(dòng)腫瘤細(xì)胞的惡性增殖。目前針對(duì)該蛋白的藥物研發(fā)仍處于探索階段，研究人員試圖通過調(diào)控其活性來糾正錯(cuò)誤的RNA剪接，為癌癥治療開辟新路徑，但相關(guān)藥物尚未進(jìn)入臨床應(yīng)用階段。
熱銷產(chǎn)品
Recombinant Human Splicing factor U2AF 65 kDa subunit (U2AF2),Biotinylated (CSB-EP025408HU-B)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
U2AF2 Recombinant Monoclonal Antibody (CSB-RA953601A0HU)
驗(yàn)證數(shù)據(jù)
Flow cytometric analysis of U2AF2 expression in HepG2 cells using U2AF2 antibody. Green, isotype control; red, U2AF2.
Immunocytochemical staining of HepG2 cells with U2AF2 antibody. Nuclei were stained blue with DAPI; U2AF2 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
Western blotting analysis using U2AF2 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with U2AF2 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
U2AF2 Antibodies
U2AF2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA025408GA01HU | U2AF2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA025408LA01HU | U2AF2 Antibody | Human | ELISA, WB |
| CSB-PA025408LB01HU | U2AF2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA025408LC01HU | U2AF2 Antibody, FITC conjugated | Human | |
| CSB-RA043670A0HU | U2AF2 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, IHC, IF, FC |
| CSB-RA953601A0HU | U2AF2 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, FC, ICC |
U2AF2 Proteins
U2AF2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025408HU CSB-EP025408HU CSB-BP025408HU CSB-MP025408HU |
Recombinant Human Splicing factor U2AF 65 kDa subunit (U2AF2) | Yeast E.coli Baculovirus Mammalian cell |
| CSB-EP025408HU-B | Recombinant Human Splicing factor U2AF 65 kDa subunit (U2AF2),Biotinylated | E.coli |
| CSB-EP025408HUe0 | Recombinant Human Splicing factor U2AF 65 kDa subunit (U2AF2) | E.coli |
