WAC
WAC，全稱為含WW結構域卷曲螺旋銜接蛋白，常見別名有BM-016、DESSH、PRO1741，主要定位于細胞核，作為銜接分子參與基因轉錄與染色質調控，同時維系細胞自噬與線粒體穩態，在神經發育與細胞正常增殖中起到關鍵支撐作用。
WAC異常與多種疾病相關，突變可引發Desanto-Shinawi綜合征，表現為智力障礙、發育遲緩等神經發育問題，在膠質母細胞瘤中表達下調并與不良預后相關。目前研究多集中在致病機制解析與診斷標志物開發，靶向其結構與功能的小分子調節劑仍處于臨床前篩選階段，為神經發育疾病與腦部腫瘤的診療提供潛在方向。
熱銷產品
WAC Antibody (CSB-PA861133HA01HU)
驗證數據
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA861133HA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA861133HA01HU at dilution of 1:100
Immunofluorescent analysis of MCF-7 cells using CSB-PA861133HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
WAC Antibodies
WAC for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA861133HA01HU | WAC Antibody | Human | ELISA, IHC, IF |
| CSB-PA861133HB01HU | WAC Antibody, HRP conjugated | Human | ELISA |
| CSB-PA861133HD01HU | WAC Antibody, Biotin conjugated | Human | ELISA |
WAC Proteins
WAC Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP861133HU CSB-EP861133HU CSB-BP861133HU CSB-MP861133HU CSB-EP861133HU-B |
Recombinant Human WW domain-containing adapter protein with coiled-coil (WAC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
