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WNT8A

WNT8A,全稱為WNT家族成員8A,常用別名WNT8蛋白。它是WNT信號(hào)通路相關(guān)分泌型蛋白,廣泛參與胚胎發(fā)育、組織再生、細(xì)胞增殖分化調(diào)控,對(duì)骨骼發(fā)育、神經(jīng)系統(tǒng)形成及器官穩(wěn)態(tài)維持具有關(guān)鍵作用,同時(shí)調(diào)節(jié)細(xì)胞間信號(hào)傳遞,維持組織正常結(jié)構(gòu)。 WNT8A異常高表達(dá)與多種惡性腫瘤密切相關(guān),能夠促進(jìn)腫瘤細(xì)胞增殖、上皮間質(zhì)轉(zhuǎn)化及侵襲轉(zhuǎn)移,與肺癌、結(jié)直腸癌、肝癌等腫瘤的發(fā)生發(fā)展密切相關(guān),是腫瘤不良預(yù)后的重要標(biāo)志物。目前WNT8A阻斷劑及靶向抗體處于臨床前研究階段,通過抑制其信號(hào)傳遞,阻斷腫瘤進(jìn)展,為實(shí)體腫瘤提供新型治療策略。

熱銷產(chǎn)品

WNT8A Antibody (CSB-PA863951LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA863951LA01HU

IHC image of CSB-PA863951LA01HU diluted at 1:200 and staining in paraffin-embedded human gastric cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA863951LA01HU

IHC image of CSB-PA863951LA01HU diluted at 1:200 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

WNT8A Antibodies

WNT8A for Homo sapiens (Human)

WNT8A Proteins

WNT8A Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

WNT8A Proteins for Mus musculus (Mouse)

WNT8A Proteins for Homo sapiens (Human)



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