ZFX

ZFX，全稱為X連鎖鋅指蛋白，常用別名鋅指蛋白9A。它是一種高度保守的核內(nèi)轉(zhuǎn)錄蛋白，廣泛表達(dá)于人體各類組織細(xì)胞中，參與干細(xì)胞自我更新、細(xì)胞增殖調(diào)控以及胚胎發(fā)育過程，能夠穩(wěn)定細(xì)胞生長狀態(tài)，維持機(jī)體正常組織器官生理功能。
ZFX異常高表達(dá)會顯著促進(jìn)腫瘤細(xì)胞惡性增殖、侵襲與轉(zhuǎn)移，與白血病、肝癌、胃癌、結(jié)直腸癌等多種惡性腫瘤密切相關(guān)，其表達(dá)水平越高，往往代表腫瘤侵襲性越強(qiáng)、預(yù)后越差，同時也可作為腫瘤預(yù)后評估標(biāo)志物。目前針對ZFX的靶向抑制藥物仍處于臨床前研究階段，主要通過下調(diào)該蛋白表達(dá)阻斷腫瘤惡性進(jìn)展，有望為血液腫瘤及實(shí)體惡性腫瘤治療提供全新潛在方案。

熱銷產(chǎn)品

ZFX Antibody (CSB-PA026467LA01HU)

驗(yàn)證數(shù)據(jù)

IHC image of CSB-PA026467LA01HU diluted at 1:400 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

ZFX Antibody

ZFX Protein

ZFX Antibodies

ZFX for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA026467LA01HU	ZFX Antibody	Human	ELISA, IHC
CSB-PA026467LC01HU	ZFX Antibody, FITC conjugated	Human
CSB-PA026467LD01HU	ZFX Antibody, Biotin conjugated	Human	ELISA

ZFX Proteins

ZFX Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP026467HU CSB-EP026467HU CSB-BP026467HU CSB-MP026467HU CSB-EP026467HU-B	Recombinant Human Zinc finger X-chromosomal protein (ZFX), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli