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  4. Recombinant Mouse Gamma-aminobutyric acid receptor subunit rho-1 (Gabrr1), partial

Recombinant Mouse Gamma-aminobutyric acid receptor subunit rho-1 (Gabrr1), partial

  • 中文名稱：
    小鼠Gabrr1重組蛋白
  • 貨號：
    CSB-YP009156MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Gabrr1重組蛋白
  • 貨號：
    CSB-EP009156MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Gabrr1重組蛋白
  • 貨號：
    CSB-EP009156MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Gabrr1重組蛋白
  • 貨號：
    CSB-BP009156MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Gabrr1重組蛋白
  • 貨號：
    CSB-MP009156MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Gabrr1
  • Uniprot No.：
  • 別名：
    Gabrr1Gamma-aminobutyric acid receptor subunit rho-1; GABA(A) receptor subunit rho-1; GABA(C) receptor
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission.
  • 基因功能參考文獻：
    1. GABACR antagonists differed in their effects on nSTR and PhNR; antagonists with GABAB agonist properties enhanced light-driven responses whereas 2-AEMP did not. PMID: 26164072
    2. GABArho has a role in the bicuculline-insensitive component of GFAP+ cells of cerebellum PMID: 25422464
    3. Ethanol action on GABAA receptors containing rho1/rho2 subunits may be important for specific effects of ethanol in vivo. PMID: 24454882
    4. Identification of a fragment flanking the GABArho1 gene promoter paves the way for studies of molecular elements that control GABArho1 transcription and regulate its expression during retinal development. PMID: 23106649
    5. GABA(C) receptors play a general role for the control of neuronal excitability in subcortical visual pathways. PMID: 19902194
    6. activation of peripheral GABA-Rs may provide a new modality to modulate T cell, B cell, and APC activity and help ameliorate RA and other inflammatory diseases. PMID: 21604972
    7. the GABA receptor/channel rho 1 subunit plays an important role in modulating spinal cord pain transmission functions in vivo PMID: 12970343
    8. GABA(C) receptors and protein phosphatase 1 (PP1) simultaneously bind to different domains of PNUTS, the targeting subunit of PP1. PMID: 18325784
    9. In GABA(C) rho1 Null stratum griseum superficiale (SGS) cells, inhibitory postsynaptic currents were shorter in duration and their excitatory postsynaptic currents were longer, indicating that a slow GABA(C)R-mediated inhibitory component was reduced. PMID: 19321639

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  • 亞細胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRR1 sub-subfamily
  • 數據庫鏈接：


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